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Karl Köhrer

TitleProf.
InstitutionHeinrich-Heine-University Duesseldorf
DepartmentGenomics & Transcriptomics Laboratory
AddressDuesseldorf 40225
Phone+49 (0)221-81 13165
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vicente Dueñas C, Janssen S, Oldenburg M, Auer F, González Herrero I, Casado-García A, Isidro-Hernández M, Raboso-Gallego J, Westhoff P, Pandyra AA, Hein D, Gössling KL, Alonso-López D, De Las Rivas J, Bhatia S, Garcia-Criado FJ, García Cenador MB, Weber APM, Köhrer K, Hauer J, Fischer U, Sanchez-Garcia I, Borkhardt A. An intact gut microbiome protects genetically predisposed mice against leukemia. Blood. 2020 Sep 10. PMID: 32911536.
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    2. Skowron MA, Vermeulen M, Winkelhausen A, Becker TK, Bremmer F, Petzsch P, Schönberger S, Calaminus G, Köhrer K, Albers P, Nettersheim D. CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms. Br J Cancer. 2020 Aug; 123(3):378-391. PMID: 32418994.
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    3. Lang A, Whongsiri P, Yilmaz M, Lautwein T, Petzsch P, Greife A, Günes C, Köhrer K, Niegisch G, Hoffmann M, Schulz WA. Knockdown of UTX/KDM6A Enriches Precursor Cell Populations in Urothelial Cell Cultures and Cell Lines. Cancers (Basel). 2020 Apr 21; 12(4). PMID: 32326336.
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    4. Brenig K, Grube L, Schwarzländer M, Köhrer K, Stühler K, Poschmann G. The Proteomic Landscape of Cysteine Oxidation That Underpins Retinoic Acid-Induced Neuronal Differentiation. J Proteome Res. 2020 May 01; 19(5):1923-1940. PMID: 32202429.
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    5. Owenier C, Hesse J, Alter C, Ding Z, Marzoq A, Petzsch P, Köhrer K, Schrader J. Novel technique for the simultaneous isolation of cardiac fibroblasts and epicardial stromal cells from the infarcted murine heart. Cardiovasc Res. 2020 Apr 01; 116(5):1047-1058. PMID: 31504244.
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    6. Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster I, Hochrath K, Schumak B, Ventura N, Petzsch P, Köhrer K, Esser C. AHR Signaling Dampens Inflammatory Signature in Neonatal Skin ?d T Cells. Int J Mol Sci. 2020 Mar 24; 21(6). PMID: 32213963.
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    7. Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun. 2020 03 12; 11(1):1338. PMID: 32165633.
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    8. Nimtz L, Hartmann J, Tigges J, Masjosthusmann S, Schmuck M, Keßel E, Theiss S, Köhrer K, Petzsch P, Adjaye J, Wigmann C, Wieczorek D, Hildebrandt B, Bendt F, Hübenthal U, Brockerhoff G, Fritsche E. Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation. Stem Cell Res. 2020 05; 45:101761. PMID: 32244191.
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    9. Wang C, Hamacher A, Petzsch P, Köhrer K, Niegisch G, Hoffmann MJ, Schulz WA, Kassack MU. Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1. Cancers (Basel). 2020 Feb 03; 12(2). PMID: 32028599.
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    10. Hänsch S, Spona D, Murra G, Köhrer K, Subtil A, Furtado AR, Lichtenthaler SF, Dislich B, Mölleken K, Hegemann JH. Chlamydia-induced curvature of the host-cell plasma membrane is required for infection. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2634-2644. PMID: 31964834.
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    11. Klindt C, Reich M, Hellwig B, Stindt J, Rahnenführer J, Hengstler JG, Köhrer K, Schoonjans K, Häussinger D, Keitel V. The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver. Cells. 2019 11 19; 8(11). PMID: 31752395.
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    12. Skowron MA, Petzsch P, Hardt K, Wagner N, Beier M, Stepanow S, Drechsler M, Rieder H, Köhrer K, Niegisch G, Hoffmann MJ, Schulz WA. Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines. Sci Rep. 2019 10 09; 9(1):14476. PMID: 31597922.
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    13. Ehlting C, Rex J, Albrecht U, Deenen R, Tiedje C, Köhrer K, Sawodny O, Gaestel M, Häussinger D, Bode JG. Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide. Sci Rep. 2019 07 30; 9(1):11021. PMID: 31363109.
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    14. Brandenburger T, Johannsen L, Prassek V, Kuebart A, Raile J, Wohlfromm S, Köhrer K, Huhn R, Hollmann MW, Hermanns H. MiR-34a is differentially expressed in dorsal root ganglia in a rat model of chronic neuropathic pain. Neurosci Lett. 2019 08 24; 708:134365. PMID: 31278961.
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    15. Trossbach SV, Hecher L, Schafflick D, Deenen R, Popa O, Lautwein T, Tschirner S, Köhrer K, Fehsel K, Papazova I, Malchow B, Hasan A, Winterer G, Schmitt A, Meyer Zu Hörste G, Falkai P, Korth C. Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia. Transl Psychiatry. 2019 05 31; 9(1):156. PMID: 31150013.
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    16. Jaguva Vasudevan AA, Hoffmann MJ, Beck MLC, Poschmann G, Petzsch P, Wiek C, Stühler K, Köhrer K, Schulz WA, Niegisch G. HDAC5 Expression in Urothelial Carcinoma Cell Lines Inhibits Long-Term Proliferation but Can Promote Epithelial-to-Mesenchymal Transition. Int J Mol Sci. 2019 Apr 30; 20(9). PMID: 31052182.
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    17. Lang A, Yilmaz M, Hader C, Murday S, Kunz X, Wagner N, Wiek C, Petzsch P, Köhrer K, Koch J, Hoffmann MJ, Greife A, Schulz WA. Contingencies of UTX/KDM6A Action in Urothelial Carcinoma. Cancers (Basel). 2019 Apr 04; 11(4). PMID: 30987376.
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    18. Wiegering A, Petzsch P, Köhrer K, Rüther U, Gerhardt C. GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis. Dev Biol. 2019 06 15; 450(2):141-154. PMID: 30953627.
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    19. Benga L, Feßler AT, Benten WPM, Engelhardt E, Köhrer K, Schwarz S, Sager M. Acinetobacter species in laboratory mice: species survey and antimicrobial resistance. Lab Anim. 2019 Oct; 53(5):470-477. PMID: 30567464.
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    20. Heinen A, Nederlof R, Panjwani P, Spychala A, Tschaidse T, Reffelt H, Boy J, Raupach A, Gödecke S, Petzsch P, Köhrer K, Grandoch M, Petz A, Fischer JW, Alter C, Vasilevska J, Lang P, Gödecke A. IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells. Mol Ther. 2019 01 02; 27(1):46-58. PMID: 30528085.
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    21. Singh M, Bergmann L, Lang A, Pexa K, Kuck F, Stibane D, Janke L, Ezzahoini H, Lindecke A, Wiek C, Hanenberg H, Köhrer K, von Gall C, Reinke H, Piekorz RP. Gai3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver. Oncotarget. 2018 Jul 13; 9(54):30213-30224. PMID: 30100984.
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    22. Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Köhrer K, Deenen R, Unfried K, Altschmied J, Haendeler J. CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. PLoS Biol. 2018 06; 16(6):e2004408. PMID: 29927970.
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    23. Wendel AF, Meyer S, Deenen R, Köhrer K, Kolbe-Busch S, Pfeffer K, Willmann M, Kaasch AJ, MacKenzie CR. Long-Term, Low-Frequency Cluster of a German-Imipenemase-1-Producing Enterobacter hormaechei ssp. steigerwaltii ST89 in a Tertiary Care Hospital in Germany. Microb Drug Resist. 2018 Nov; 24(9):1305-1315. PMID: 29750595.
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    24. Masjosthusmann S, Becker D, Petzuch B, Klose J, Siebert C, Deenen R, Barenys M, Baumann J, Dach K, Tigges J, Hübenthal U, Köhrer K, Fritsche E. A transcriptome comparison of time-matched developing human, mouse and rat neural progenitor cells reveals human uniqueness. Toxicol Appl Pharmacol. 2018 09 01; 354:40-55. PMID: 29753005.
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    25. Suwala AK, Koch K, Rios DH, Aretz P, Uhlmann C, Ogorek I, Felsberg J, Reifenberger G, Köhrer K, Deenen R, Steiger HJ, Kahlert UD, Maciaczyk J. Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro. Oncotarget. 2018 Apr 27; 9(32):22703-22716. PMID: 29854309.
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    26. Ballmann C, Thiel A, Korah HE, Reis AC, Saeger W, Stepanow S, Köhrer K, Reifenberger G, Knobbe-Thomsen CB, Knappe UJ, Scholl UI. USP8 Mutations in Pituitary Cushing Adenomas-Targeted Analysis by Next-Generation Sequencing. J Endocr Soc. 2018 Mar 01; 2(3):266-278. PMID: 29600293.
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    27. Hirsch B, Endris V, Lassmann S, Weichert W, Pfarr N, Schirmacher P, Kovaleva V, Werner M, Bonzheim I, Fend F, Sperveslage J, Kaulich K, Zacher A, Reifenberger G, Köhrer K, Stepanow S, Lerke S, Mayr T, Aust DE, Baretton G, Weidner S, Jung A, Kirchner T, Hansmann ML, Burbat L, von der Wall E, Dietel M, Hummel M. Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics. Virchows Arch. 2018 Apr; 472(4):557-565. PMID: 29374318.
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    28. Wammers M, Schupp AK, Bode JG, Ehlting C, Wolf S, Deenen R, Köhrer K, Häussinger D, Graf D. Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids. Sci Rep. 2018 01 10; 8(1):255. PMID: 29321478.
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    29. Eder T, Kobus S, Stallmann S, Stepanow S, Köhrer K, Hegemann JH, Rattei T. Genome sequencing of Chlamydia trachomatis serovars E and F reveals substantial genetic variation. Pathog Dis. 2017 12 29; 75(9). PMID: 29186396.
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    30. Henrich B, Kretzmer F, Deenen R, Köhrer K. Validation of a novel Mho microarray for a comprehensive characterisation of the Mycoplasma hominis action in HeLa cell infection. PLoS One. 2017; 12(7):e0181383. PMID: 28753664.
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    31. Seyfarth J, Förtsch K, Ahlert H, Laws HJ, Karges B, Deenen R, Köhrer K, Mayatepek E, Meissner T, Jacobsen M. Dominant TNFa and impaired IL-2 cytokine profiles of CD4+ T cells from children with type-1 diabetes. Immunol Cell Biol. 2017 08; 95(7):630-639. PMID: 28377612.
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    32. Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice. PLoS Pathog. 2016 Dec; 12(12):e1006043. PMID: 27936238.
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    33. Keitel V, Dröge C, Stepanow S, Fehm T, Mayatepek E, Köhrer K, Häussinger D. Intrahepatic cholestasis of pregnancy (ICP): case report and review of the literature. Z Gastroenterol. 2016 Dec; 54(12):1327-1333. PMID: 27936482.
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    34. Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med. 2016 10 26; 8(362):362ra146. PMID: 27797962.
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    35. Wilk CM, Heinzler N, Boquoi A, Cadeddu RP, Strapatsas T, Dienst A, Majidi F, Deenen R, Bruns I, Schroeder T, Köhrer K, Haas R, Kobbe G, Fenk R. Lenalidomide consolidation treatment in patients with multiple myeloma suppresses myelopoieses but spares erythropoiesis. Int J Cancer. 2016 Nov 15; 139(10):2343-52. PMID: 27389073.
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    36. Haas K, Weighardt H, Deenen R, Köhrer K, Clausen B, Zahner S, Boukamp P, Bloch W, Krutmann J, Esser C. Aryl Hydrocarbon Receptor in Keratinocytes Is Essential for Murine Skin Barrier Integrity. J Invest Dermatol. 2016 11; 136(11):2260-2269. PMID: 27430407.
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    37. Neumann E, Brandenburger T, Santana-Varela S, Deenen R, Köhrer K, Bauer I, Hermanns H, Wood JN, Zhao J, Werdehausen R. MicroRNA-1-associated effects of neuron-specific brain-derived neurotrophic factor gene deletion in dorsal root ganglia. Mol Cell Neurosci. 2016 09; 75:36-43. PMID: 27346077.
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    38. Rammos C, Hendgen-Cotta UB, Totzeck M, Pohl J, Lüdike P, Flögel U, Deenen R, Köhrer K, French BA, Gödecke A, Kelm M, Rassaf T. Impact of dietary nitrate on age-related diastolic dysfunction. Eur J Heart Fail. 2016 06; 18(6):599-610. PMID: 27118445.
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    39. Zacher A, Kaulich K, Stepanow S, Wolter M, Köhrer K, Felsberg J, Malzkorn B, Reifenberger G. Molecular Diagnostics of Gliomas Using Next Generation Sequencing of a Glioma-Tailored Gene Panel. Brain Pathol. 2017 03; 27(2):146-159. PMID: 26919320.
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    40. Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP. MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging (Albany NY). 2016 Mar; 8(3):484-505. PMID: 26959556.
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    41. Pinkerneil M, Hoffmann MJ, Deenen R, Köhrer K, Arent T, Schulz WA, Niegisch G. Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms. . 2016 Feb; 15(2):299-312. PMID: 26772204.
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    42. Drusenheimer N, Migdal B, Jäckel S, Tveriakhina L, Scheider K, Schulz K, Gröper J, Köhrer K, Klein T. The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. PLoS Genet. 2015 Dec; 11(12):e1005749. PMID: 26720614.
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    43. Sorg UR, Behnke K, Degrandi D, Reich M, Keitel V, Herebian D, Deenen R, Beyer M, Schultze JL, Köhrer K, Gabbert HE, Mayatepek E, Häussinger D, Pfeffer K. Cooperative role of lymphotoxin ß receptor and tumor necrosis factor receptor p55 in murine liver regeneration. J Hepatol. 2016 May; 64(5):1108-1117. PMID: 26708145.
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    44. Kiene LS, Homann S, Suvorava T, Rabausch B, Müller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S, Köhrer K, Savani RC, Grandoch M, Fischer JW. Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):e9-16. PMID: 26586662.
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    45. Rammos C, Totzeck M, Deenen R, Köhrer K, Kelm M, Rassaf T, Hendgen-Cotta UB. Dietary nitrate is a modifier of vascular gene expression in old male mice. Oxid Med Cell Longev. 2015; 2015:658264. PMID: 25838870.
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    46. Grandoch M, Feldmann K, Göthert JR, Dick LS, Homann S, Klatt C, Bayer JK, Waldheim JN, Rabausch B, Nagy N, Oberhuber A, Deenen R, Köhrer K, Lehr S, Homey B, Pfeffer K, Fischer JW. Deficiency in lymphotoxin ß receptor protects from atherosclerosis in apoE-deficient mice. Circ Res. 2015 Apr 10; 116(8):e57-68. PMID: 25740843.
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    47. Freudenberger T, Deenen R, Kretschmer I, Zimmermann A, Seiler LF, Mayer P, Heim HK, Köhrer K, Fischer JW. Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice. Br J Pharmacol. 2014 Nov; 171(22):5032-48. PMID: 24923668.
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    48. Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA. Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity. Immunity. 2014 Jun 19; 40(6):949-60. PMID: 24909887.
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    49. Benga L, Benten WP, Engelhardt E, Köhrer K, Gougoula C, Sager M. 16S ribosomal DNA sequence-based identification of bacteria in laboratory rodents: a practical approach in laboratory animal bacteriology diagnostics. Lab Anim. 2014 Oct; 48(4):305-12. PMID: 24876090.
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    50. Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F. Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol. 2014 Aug; 56:59-68. PMID: 24699405.
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    51. Bosch J, Houben AP, Hennicke T, Deenen R, Köhrer K, Liedtke S, Kögler G. Comparing the gene expression profile of stromal cells from human cord blood and bone marrow: lack of the typical "bone" signature in cord blood cells. Stem Cells Int. 2013; 2013:631984. PMID: 24163699.
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    52. Haendeler J, Mlynek A, Büchner N, Lukosz M, Graf M, Guettler C, Jakob S, Farrokh S, Kunze K, Goy C, Guardiola-Serrano F, Schaal H, Cortese-Krott M, Deenen R, Köhrer K, Winkler C, Altschmied J. Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1639-46. PMID: 23685552.
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    53. Liedtke S, Freytag EM, Bosch J, Houben AP, Radke TF, Deenen R, Köhrer K, Kögler G. Neonatal mesenchymal-like cells adapt to surrounding cells. Stem Cell Res. 2013 Jul; 11(1):634-46. PMID: 23660338.
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    54. Hopfe M, Deenen R, Degrandi D, Köhrer K, Henrich B. Host cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis. PLoS One. 2013; 8(1):e54219. PMID: 23326599.
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    55. Widera M, Erkelenz S, Hillebrand F, Krikoni A, Widera D, Kaisers W, Deenen R, Gombert M, Dellen R, Pfeiffer T, Kaltschmidt B, Münk C, Bosch V, Köhrer K, Schaal H. An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA. J Virol. 2013 Mar; 87(5):2707-20. PMID: 23255806.
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    56. Moellendorf S, Kessels C, Peiseler L, Raupach A, Jacoby C, Vogt N, Lindecke A, Koch L, Brüning J, Heger J, Köhrer K, Gödecke A. IGF-IR signaling attenuates the age-related decline of diastolic cardiac function. Am J Physiol Endocrinol Metab. 2012 Jul 15; 303(2):E213-22. PMID: 22589390.
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    57. Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, Synaeve C, Deenen R, Ginzel S, Dvorsky R, Gombert M, Halenius A, Hartig R, Helminen M, Fischer A, Stepensky P, Vettenranta K, Köhrer K, Ahmadian MR, Laws HJ, Fleckenstein B, Jumaa H, Latour S, Schraven B, Borkhardt A. Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases. Leukemia. 2012 May; 26(5):963-71. PMID: 22289921.
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    58. Buchheiser A, Ebner A, Burghoff S, Ding Z, Romio M, Viethen C, Lindecke A, Köhrer K, Fischer JW, Schrader J. Inactivation of CD73 promotes atherogenesis in apolipoprotein E-deficient mice. Cardiovasc Res. 2011 Nov 01; 92(2):338-47. PMID: 21955554.
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    59. Molojavyi A, Lindecke A, Raupach A, Moellendorf S, Köhrer K, Gödecke A. Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiol Genomics. 2010 Apr 01; 41(2):137-45. PMID: 20145201.
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    60. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I. The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31; 8:399. PMID: 17974005.
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    61. Schäfer C, Gehrmann T, Richter L, Keitel V, Köhrer K, Häussinger D, Schliess F. Modulation of gene expression profiles by hyperosmolarity and insulin. Cell Physiol Biochem. 2007; 20(5):369-86. PMID: 17762165.
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    62. Warskulat U, Andrée B, Lüsebrink J, Köhrer K, Häussinger D. Switch from actin alpha1 to alpha2 expression and upregulation of biomarkers for pressure overload and cardiac hypertrophy in taurine-deficient mouse heart. Biol Chem. 2006 Oct-Nov; 387(10-11):1449-54. PMID: 17081118.
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    63. Prick T, Thumm M, Köhrer K, Häussinger D, Vom Dahl S. In yeast, loss of Hog1 leads to osmosensitivity of autophagy. Biochem J. 2006 Feb 15; 394(Pt 1):153-61. PMID: 16321140.
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    64. Kubitz R, Keitel V, Scheuring S, Köhrer K, Häussinger D. Benign recurrent intrahepatic cholestasis associated with mutations of the bile salt export pump. J Clin Gastroenterol. 2006 Feb; 40(2):171-5. PMID: 16394881.
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    65. Dransfeld O, Gehrmann T, Köhrer K, Kircheis G, Holneicher C, Häussinger D, Wettstein M. Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver. Liver Int. 2005 Dec; 25(6):1243-58. PMID: 16343078.
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    66. Beyer A, Scheuring S, Müller S, Mincheva A, Lichter P, Köhrer K. Comparative sequence and expression analyses of four mammalian VPS4 genes. Gene. 2003 Feb 13; 305(1):47-59. PMID: 12594041.
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    67. Schmitz FJ, Beeck A, Perdikouli M, Boos M, Mayer S, Scheuring S, Köhrer K, Verhoef J, Fluit AC. Production of BRO beta-lactamases and resistance to complement in European Moraxella catarrhalis isolates. J Clin Microbiol. 2002 Apr; 40(4):1546-8. PMID: 11923393.
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    68. Schmitz FJ, Boos M, Mayer S, Köhrer K, Scheuring S, Fluit AC. In vitro activities of novel des-fluoro(6) quinolone BMS-284756 against mutants of Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus selected with different quinolones. Antimicrob Agents Chemother. 2002 Mar; 46(3):934-5. PMID: 11850293.
      Citations:    
    69. Schmitz FJ, Petridou J, Astfalk N, Köhrer K, Scheuring S, Schwarz S. Molecular analysis of constitutively expressed erm(C) genes selected in vitro by incubation in the presence of the noninducers quinupristin, telithromycin, or ABT-773. Microb Drug Resist. 2002; 8(3):171-7. PMID: 12363005.
      Citations:    
    70. Schmitz FJ, Hafner D, Geisel R, Follmann P, Kirschke C, Verhoef J, Köhrer K, Fluit AC. Increased prevalence of class I integrons in Escherichia coli, Klebsiella species, and Enterobacter species isolates over a 7-year period in a German university hospital. J Clin Microbiol. 2001 Oct; 39(10):3724-6. PMID: 11574602.
      Citations:    
    71. Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF, Köhrer K. Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. J Mol Biol. 2001 Sep 21; 312(3):469-80. PMID: 11563910.
      Citations:    
    72. Schmitz FJ, Petridou J, Astfalk N, Scheuring S, Köhrer K, Verhoef J, Fluit AC, Schwarz S. Structural alterations in the translational attenuator of constitutively expressed erm(A) genes in Staphylococcus aureus. Antimicrob Agents Chemother. 2001 May; 45(5):1603-4. PMID: 11372641.
      Citations:    
    73. Schulte KM, Beyer A, Köhrer K, Oberhäuser S, Röher HD. Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer. Int J Cancer. 2001 Apr 15; 92(2):249-56. PMID: 11291053.
      Citations:    
    74. Mayer S, Boos M, Köhrer K, Fluit AC, Schmitz FJ. In vitro development of resistance to newer fluoroquinolones in Streptococcus pneumoniae isolates with reduced susceptibility to ciprofloxacin. Eur J Clin Microbiol Infect Dis. 2001 Apr; 20(4):288-91. PMID: 11399024.
      Citations:    
    75. Boos M, Mayer S, Fischer A, Köhrer K, Scheuring S, Heisig P, Verhoef J, Fluit AC, Schmitz FJ. In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus. Antimicrob Agents Chemother. 2001 Mar; 45(3):938-42. PMID: 11181385.
      Citations:    
    76. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar; 11(3):422-35. PMID: 11230166.
      Citations:    
    77. Jones ME, Köhrer K, Schmitz FJ. Multiplex PCR for the Rapid Simultaneous Speciation and Detection of Methicillin-Resistance and Genes Encoding Toxin Production in Staphylococcus aureus. Methods Mol Med. 2001; 48:103-12. PMID: 21374410.
      Citations:    
    78. Schmitz FJ, Fluit AC, Hafner D, Beeck A, Perdikouli M, Boos M, Scheuring S, Verhoef J, Köhrer K, Von Eiff C. Development of resistance to ciprofloxacin, rifampin, and mupirocin in methicillin-susceptible and -resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2000 Nov; 44(11):3229-31. PMID: 11036061.
      Citations:    
    79. Schmitz FJ, Fluit AC, Lindenlauf E, Scheuring S, Köhrer K. Molecular analyses of possible mechanisms coding for low-level mupirocin resistance in clinical Staphylococcus aureus isolates. Eur J Clin Microbiol Infect Dis. 2000 Aug; 19(8):649-50. PMID: 11014635.
      Citations:    
    80. Schmitz FJ, Sadurski R, Kray A, Boos M, Geisel R, Köhrer K, Verhoef J, Fluit AC. Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals. J Antimicrob Chemother. 2000 Jun; 45(6):891-4. PMID: 10837446.
      Citations:    
    81. Schulte KM, Heinze M, Mengel M, Scheuring S, Köhrer K, Röher HD. Complete sequencing and mRNA expression analysis of the MEN-I gene in adrenal myelolipoma. Horm Metab Res. 2000 May; 32(5):169-73. PMID: 10871156.
      Citations:    
    82. Jones ME, Boenink NM, Verhoef J, Köhrer K, Schmitz FJ. Multiple mutations conferring ciprofloxacin resistance in Staphylococcus aureus demonstrate long-term stability in an antibiotic-free environment. J Antimicrob Chemother. 2000 Mar; 45(3):353-6. PMID: 10702556.
      Citations:    
    83. Schulte KM, Simon D, Dotzenrath C, Scheuring S, Köhrer K, Röher HD. Sequence analysis of the MEN I gene in two patients with multiple cutaneous lipomas and endocrine tumors. Horm Metab Res. 2000 Feb; 32(2):76-9. PMID: 10741690.
      Citations:    
    84. Jones ME, Sahm DF, Martin N, Scheuring S, Heisig P, Thornsberry C, Köhrer K, Schmitz FJ. Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory season. Antimicrob Agents Chemother. 2000 Feb; 44(2):462-6. PMID: 10639387.
      Citations:    
    85. Schulte KM, Mengel M, Heinze M, Simon D, Scheuring S, Köhrer K, Röher HD. Complete sequencing and messenger ribonucleic acid expression analysis of the MEN I gene in adrenal cancer. J Clin Endocrinol Metab. 2000 Jan; 85(1):441-8. PMID: 10634422.
      Citations:    
    86. Schulte KM, Heinze M, Mengel M, Simon D, Scheuring S, Köhrer K, Röher HD. MEN I gene mutations in sporadic adrenal adenomas. Hum Genet. 1999 Dec; 105(6):603-10. PMID: 10647896.
      Citations:    
    87. Schmitz FJ, Fluit AC, Brisse S, Verhoef J, Köhrer K, Milatovic D. Molecular epidemiology of quinolone resistance and comparative in vitro activities of new quinolones against European Staphylococcus aureus isolates. FEMS Immunol Med Microbiol. 1999 Dec; 26(3-4):281-7. PMID: 10575140.
      Citations:    
    88. Abts HF, Welss T, Mirmohammadsadegh A, Köhrer K, Michel G, Ruzicka T. Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. J Mol Biol. 1999 Oct 15; 293(1):29-39. PMID: 10512713.
      Citations:    
    89. Brisse S, Fluit AC, Wagner U, Heisig P, Milatovic D, Verhoef J, Scheuring S, Köhrer K, Schmitz FJ. Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones. Antimicrob Agents Chemother. 1999 Oct; 43(10):2513-6. PMID: 10508034.
      Citations:    
    90. Brisse S, Milatovic D, Fluit AC, Verhoef J, Martin N, Scheuring S, Köhrer K, Schmitz FJ. Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. Antimicrob Agents Chemother. 1999 Aug; 43(8):2051-5. PMID: 10428935.
      Citations:    
    91. Scheuring S, Bodor O, Röhricht RA, Müller S, Beyer A, Köhrer K. Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking. Gene. 1999 Jun 24; 234(1):149-59. PMID: 10393249.
      Citations:    
    92. Schmitz FJ, Köhrer K, Scheuring S, Verhoef J, Fluit A, Heinz HP, Jones ME. The stability of grlA, grlB, gyrA, gyrB and norA mutations and MIC values of five fluoroquinolones in three different clonal populations of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect. 1999 May; 5(5):287-290. PMID: 11856269.
      Citations:    
    93. Köhrer K, Lang HR, Ecker M. Experience with cardiac troponin T in difficult cases. Eur Heart J. 1998 Nov; 19 Suppl N:N38-41. PMID: 9857938.
      Citations:    
    94. Schmitz FJ, Hertel B, Hofmann B, Scheuring S, Verhoef J, Fluit AC, Heinz HP, Köhrer K, Jones ME. Relationship between mutations in the coding and promoter regions of the norA genes in 42 unrelated clinical isolates of Staphylococcus aureus and the MICs of norfloxacin for these strains. J Antimicrob Chemother. 1998 Oct; 42(4):561-3. PMID: 9818767.
      Citations:    
    95. Schulte KM, Staudt S, Niederacher D, Finken-Eigen M, Köhrer K, Goretzki PE, Röher HD. Rare loss of heterozygosity of the MTS1 and MTS2 tumor suppressor genes in differentiated human thyroid cancer. Horm Metab Res. 1998 Sep; 30(9):549-54. PMID: 9808321.
      Citations:    
    96. Schmitz FJ, Jones ME, Hofmann B, Hansen B, Scheuring S, Lückefahr M, Fluit A, Verhoef J, Hadding U, Heinz HP, Köhrer K. Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC. Antimicrob Agents Chemother. 1998 May; 42(5):1249-52. PMID: 9593159.
      Citations:    
    97. Mirmohammadsadegh A, Homey B, Abts HF, Köhrer K, Ruzicka T, Michel G. Differential modulation of pro- and anti-inflammatory cytokine receptors by N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxy-crotonic acid amide (A77 1726), the physiologically active metabolite of the novel immunomodulator leflunomide. Biochem Pharmacol. 1998 May 01; 55(9):1523-9. PMID: 10076546.
      Citations:    
    98. Schmitz FJ, Hofmann B, Hansen B, Scheuring S, Lückefahr M, Klootwijk M, Verhoef J, Fluit A, Heinz HP, Köhrer K, Jones ME. Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus. J Antimicrob Chemother. 1998 Apr; 41(4):481-4. PMID: 9598779.
      Citations:    
    99. Schmitz FJ, Steiert M, Hofmann B, Verhoef J, Hadding U, Heinz HP, Köhrer K. Development of a multiplex-PCR for direct detection of the genes for enterotoxin B and C, and toxic shock syndrome toxin-1 in Staphylococcus aureus isolates. J Med Microbiol. 1998 Apr; 47(4):335-40. PMID: 9569000.
      Citations:    
    100. Schmitz FJ, Steiert M, Tichy HV, Hofmann B, Verhoef J, Heinz HP, Köhrer K, Jones ME. Typing of methicillin-resistant Staphylococcus aureus isolates from Düsseldorf by six genotypic methods. J Med Microbiol. 1998 Apr; 47(4):341-51. PMID: 9569001.
      Citations:    
    101. Schüssler P, Köhrer K, Finken-Eigen M, Michel A, Grevelding CG, Kunz W. A female-specific cDNA sequence of Schistosoma mansoni encoding an amidase that is expressed in the gastrodermis. Parasitology. 1998 Feb; 116 ( Pt 2):131-7. PMID: 9509022.
      Citations:    
    102. Schulte KM, Antoch G, Ellrichmann M, Finken-Eigen M, Köhrer K, Simon D, Goretzki PE, Röher HD. Regulation of the HGF-receptor c-met in the thyroid gland. Exp Clin Endocrinol Diabetes. 1998; 106(4):310-8. PMID: 9792464.
      Citations:    
    103. Finken-Eigen M, Müller S, Köhrer K. Cloning and characterization of a dominant-negative vps1 allele of the yeast Saccharomyces cerevisiae. Biol Chem. 1997 Oct; 378(10):1187-91. PMID: 9372190.
      Citations:    
    104. Schmitz FJ, Mackenzie CR, Hofmann B, Verhoef J, Finken-Eigen M, Heinz HP, Köhrer K. Specific information concerning taxonomy, pathogenicity and methicillin resistance of staphylococci obtained by a multiplex PCR. J Med Microbiol. 1997 Sep; 46(9):773-8. PMID: 9291889.
      Citations:    
    105. Abts HF, Breuhahn K, Michel G, Köhrer K, Esser P, Ruzicka T. Analysis of UVB-modulated gene expression in human keratinocytes by mRNA differential display polymerase chain reaction. Photochem Photobiol. 1997 Sep; 66(3):363-7. PMID: 9297979.
      Citations:    
    106. Finken-Eigen M, Röhricht RA, Köhrer K. The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment. Curr Genet. 1997 Jun; 31(6):469-80. PMID: 9211789.
      Citations:    
    107. Fingen-Eigen M, Domdey H, Köhrer K. The ribosomal protein gene RPS3 is an essential single copy gene of the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1996 Jun 14; 223(2):397-403. PMID: 8670293.
      Citations:    
    108. Rieder SE, Banta LM, Köhrer K, McCaffery JM, Emr SD. Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Mol Biol Cell. 1996 Jun; 7(6):985-99. PMID: 8817003.
      Citations:    
    109. Köhrer K, Emr SD. The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. J Biol Chem. 1993 Jan 05; 268(1):559-69. PMID: 8416961.
      Citations:    
    110. Köhrer K, Domdey H. Preparation of high molecular weight RNA. Methods Enzymol. 1991; 194:398-405. PMID: 1706459.
      Citations:    
    111. Köhrer K, Vogel K, Domdey H. A yeast tRNA precursor containing a pre-mRNA intron is spliced via the pre-mRNA splicing mechanism. EMBO J. 1990 Mar; 9(3):705-9. PMID: 2178925.
      Citations:    
    112. Köhrer K, Kutchan TM, Domdey H. Specific oligodeoxynucleotide probes obtained through RNA sequencing. DNA. 1989 Mar; 8(2):143-7. PMID: 2924686.
      Citations:    
    113. Köhrer K, Domdey H. Splicing and spliceosome formation of the yeast MATa1 transcript require a minimum distance from the 5' splice site to the internal branch acceptor site. Nucleic Acids Res. 1988 Oct 25; 16(20):9457-75. PMID: 3054807.
      Citations:    
    114. Köhrer K, Grummt I, Horak I. Functional RNA polymerase II promoters in solitary retroviral long terminal repeats (LTR-IS elements). Nucleic Acids Res. 1985 Apr 11; 13(7):2631-45. PMID: 2987860.
      Citations:    
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